USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: CSK_HUMAN USC-OGP 2-DE database:  CSK_HUMAN CSK_HUMAN General information about the entry View entry in simple text format Entry name CSK_HUMAN Primary accession number P41240 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tyrosine-protein kinase CSK; EC=2.7.10.2 {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:7683130, ECO:0000269|PubMed:9281320}; AltName: Full=C-Src kinase; AltName: Full=Protein-tyrosine kinase CYL;. Gene name Name=CSK Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0926: pI=6.85; Mw=45387 Cross-references UniProtKB/Swiss-Prot P41240; CSK_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CSK_HUMAN Primary accession number P41240 Secondary accession number(s) Q2M3N2 Q6FGZ6 Sequence was last modified on  February 1, 1995 (version 1) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=Tyrosine-protein kinase CSK; EC=2.7.10.2 {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:7683130, ECO:0000269|PubMed:9281320}; AltName: Full=C-Src kinase; AltName: Full=Protein-tyrosine kinase CYL; Gene name Name=CSK Encoded on Name=CSK Keywords 3D-structure; Acetylation; Adaptive immunity; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Immunity; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X60114; CAA42713.1; -; mRNA EMBL X59932; CAA42556.1; -; mRNA EMBL X74765; CAB58562.1; -; Genomic_DNA EMBL CR541960; CAG46758.1; -; mRNA EMBL DQ075211; AAY57329.1; -; Genomic_DNA EMBL BC104847; AAI04848.1; -; mRNA EMBL BC104875; AAI04876.1; -; mRNA EMBL BC106073; AAI06074.1; -; mRNA CCDS CCDS10269.1; -; . PIR JH0559; JH0559; . RefSeq NP_001120662.1; NM_001127190.1; . RefSeq NP_004374.1; NM_004383.2; . RefSeq XP_005254222.1; XM_005254165.4; . RefSeq XP_016877414.1; XM_017021925.1; . UniGene Hs.77793; -; . PDB 1BYG; X-ray; 2.40 A; A=173-450 PDB 1CSK; X-ray; 2.50 A; A/B/C/D=1-71 PDB 3D7T; X-ray; 2.90 A; A=188-450 PDB 3D7U; X-ray; 4.11 A; A/C=188-450 PDB 3EAC; X-ray; 1.37 A; A=73-178 PDB 3EAZ; X-ray; 1.31 A; A=73-178 PDBsum 1BYG; -; . PDBsum 1CSK; -; . PDBsum 3D7T; -; . PDBsum 3D7U; -; . PDBsum 3EAC; -; . PDBsum 3EAZ; -; . ProteinModelPortal P41240; -; . SMR P41240; -; . BioGrid 107832; 54; . IntAct P41240; 38; . MINT MINT-85878; -; . STRING 9606.ENSP00000220003; -; . BindingDB P41240; -; . ChEMBL CHEMBL2634; -; . DrugBank DB02010; Staurosporine; . DrugBank DB05075; TG100801; . GuidetoPHARMACOLOGY 1994; -; . iPTMnet P41240; -; . PhosphoSitePlus P41240; -; . BioMuta CSK; -; . DMDM 729887; -; . OGP P41240; -; . EPD P41240; -; . MaxQB P41240; -; . PaxDb P41240; -; . PeptideAtlas P41240; -; . PRIDE P41240; -; . DNASU 1445; -; . Ensembl ENST00000220003; ENSP00000220003; ENSG00000103653; . Ensembl ENST00000439220; ENSP00000414764; ENSG00000103653; . Ensembl ENST00000567571; ENSP00000454906; ENSG00000103653; . GeneID 1445; -; . KEGG hsa:1445; -; . UCSC uc002ays.3; human; . CTD 1445; -; . DisGeNET 1445; -; . GeneCards CSK; -; . HGNC HGNC:2444; CSK; . HPA CAB011203; -; . HPA HPA026488; -; . HPA HPA028425; -; . MIM 124095; gene; . neXtProt NX_P41240; -; . OpenTargets ENSG00000103653; -; . PharmGKB PA26946; -; . eggNOG KOG0197; Eukaryota; . eggNOG COG0515; LUCA; . GeneTree ENSGT00760000119011; -; . HOGENOM HOG000233858; -; . HOVERGEN HBG008761; -; . InParanoid P41240; -; . KO K05728; -; . OMA TRDPNWY; -; . OrthoDB EOG091G05PB; -; . PhylomeDB P41240; -; . TreeFam TF351634; -; . BRENDA 2.7.10.2; 2681; . Reactome R-HSA-180292; GAB1 signalosome; . Reactome R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-389948; PD-1 signaling; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . SignaLink P41240; -; . SIGNOR P41240; -; . EvolutionaryTrace P41240; -; . GeneWiki C-src_tyrosine_kinase; -; . GenomeRNAi 1445; -; . PRO PR:P41240; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000103653; -; . CleanEx HS_CSK; -; . ExpressionAtlas P41240; baseline and differential; . Genevisible P41240; HS; . GO GO:0005911; C:cell-cell junction; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; TAS:HGNC; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central; . GO GO:0045121; C:membrane raft; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IPI:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0016301; F:kinase activity; TAS:Reactome; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central; . GO GO:0008022; F:protein C-terminus binding; TAS:ProtInc; . GO GO:0034236; F:protein kinase A catalytic subunit binding; IPI:UniProtKB; . GO GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome; . GO GO:0005102; F:receptor binding; IBA:GO_Central; . GO GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW; . GO GO:0034332; P:adherens junction organization; IBA:GO_Central; . GO GO:0007420; P:brain development; IEA:Ensembl; . GO GO:0030154; P:cell differentiation; IBA:GO_Central; . GO GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Ensembl; . GO GO:0007417; P:central nervous system development; IBA:GO_Central; . GO GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0045087; P:innate immune response; IBA:GO_Central; . GO GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl; . GO GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl; . GO GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl; . GO GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport; IDA:UniProtKB; . GO GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl; . GO GO:0033673; P:negative regulation of kinase activity; IEA:Ensembl; . GO GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IEA:Ensembl; . GO GO:0050765; P:negative regulation of phagocytosis; IEA:Ensembl; . GO GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl; . GO GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central; . GO GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl; . GO GO:0006468; P:protein phosphorylation; TAS:ProtInc; . GO GO:0042127; P:regulation of cell proliferation; IBA:GO_Central; . GO GO:0001817; P:regulation of cytokine production; IBA:GO_Central; . GO GO:0060368; P:regulation of Fc receptor mediated stimulatory signaling pathway; IBA:GO_Central; . GO GO:0031295; P:T cell costimulation; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central; . Gene3D 3.30.505.10; -; 1; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR000719; Prot_kinase_dom; . InterPro IPR017441; Protein_kinase_ATP_BS; . InterPro IPR001245; Ser-Thr/Tyr_kinase_cat_dom; . InterPro IPR000980; SH2; . InterPro IPR001452; SH3_domain; . InterPro IPR008266; Tyr_kinase_AS; . InterPro IPR020635; Tyr_kinase_cat_dom; . Pfam PF07714; Pkinase_Tyr; 1; . Pfam PF00017; SH2; 1; . Pfam PF00018; SH3_1; 1; . PRINTS PR00401; SH2DOMAIN; . PRINTS PR00109; TYRKINASE; . SMART SM00252; SH2; 1; . SMART SM00326; SH3; 1; . SMART SM00219; TyrKc; 1; . SUPFAM SSF50044; SSF50044; 1; . SUPFAM SSF55550; SSF55550; 1; . SUPFAM SSF56112; SSF56112; 1; . PROSITE PS00107; PROTEIN_KINASE_ATP; 1; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; . PROSITE PS00109; PROTEIN_KINASE_TYR; 1; . PROSITE PS50001; SH2; 1; . PROSITE PS50002; SH3; 1; .

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